Based on Simon Willison's original 2005 eTech talk, Simon expands this into a full article covering the expressive functionality of JavaScript. He covers the basics of JavaScript: literals, variables, functions, scope, control flow, objects, classes, inner functions and closures. Everything a developer needs to know before diving into more advanced JavaScript.
A simplified explanation of closures by Morris Johns: A closure is the local variables for a function - kept alive after the function has returned.
A stackoverflow community article explaining closures in plain simple English does a great job. Succinctly: a closure is created when inner function that gets returned. The inner function can still see the variables and methods defined in the outer function.